scottyc33

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Total Posts: 139

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May 2010

August 13, 2010, 02:49 PM

http://www.ncbi.nlm.nih.gov/pubmed/16387899

Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases.
Bengmark S.

Institute of Hepatology, University College, London Medical School, London, United Kingdom. .(JavaScript must be enabled to view this email address)

Comment in:

JPEN J Parenter Enteral Nutr. 2006 Jan-Feb;30(1):61-2.

Abstract
BACKGROUND: The world suffers a tsunami of chronic diseases, and a typhoon of acute illnesses, many of which are associated with the inappropriate or exaggerated activation of genes involved in inflammation. Finding therapeutic agents which can modulate the inflammatory reaction is the highest priority in medical research today. Drugs developed by the pharmaceutical industry have thus far been associated with toxicity and side effects, which is why natural substances are of increasing interest. METHODS: A literature search (PubMed) showed almost 1500 papers dealing with curcumin, most from recent years. All available abstracts were read. Approximately 300 full papers were reviewed. RESULTS: Curcumin, a component of turmeric, has been shown to be non-toxic, to have antioxidant activity, and to inhibit such mediators of inflammation as NFkappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS). Significant preventive and/or curative effects have been observed in experimental animal models of a number of diseases, including arteriosclerosis, cancer, diabetes, respiratory, hepatic, pancreatic, intestinal and gastric diseases, neurodegenerative and eye diseases. CONCLUSIONS: Turmeric, an approved food additive, or its component curcumin, has shown surprisingly beneficial effects in experimental studies of acute and chronic diseases characterized by an exaggerated inflammatory reaction. There is ample evidence to support its clinical use, both as a prevention and a treatment. Several natural substances have greater antioxidant effects than conventional vitamins, including various polyphenols, flavonoids and curcumenoids. Natural substances are worth further exploration both experimentally and clinically.

scottyc33

Editor

Total Posts: 139

Member Since:
May 2010

[ # 1 ]

September 08, 2010, 03:14 PM

http://anti-agingfirewalls.com/2010/08/24/neurogenesis-curcumin-and-longevity/

“If you do a search in this blog or in my treatise for curcumin, you will see that it long has been one of the favorite substances in my anti-aging firewall regimen for good reasons: it is anti-inflammatory, it is known to combat numerous cancers, it inhibits the expression of NF-kappaB, it can help regulate P53, P21, CASP9 and other genes which control apoptosis, inhibition of cell growth and cell cycle arrest so as to maintain a line of cells in a healthy state, it is a COX-2 enzyme inhibitor, it protects against bone loss, it chelates heavy metals – and the list goes on and on.  The actions of this substance are complex.  For example, it appears that curcumin acts to control the proliferation of neurogliaoma cells by modulating gene expression related to at least four different pathways: oxidative stress, cell cycle control, and DNA transcription and metabolism(ref). “

scottyc33

Editor

Total Posts: 139

Member Since:
May 2010

[ # 2 ]

March 04, 2011, 09:35 AM

http://articles.mercola.com/sites/articles/archive/2011/03/02/common-spice-protects-and-rebuild-brain-cells-after-stroke.aspx