PQQ A Hair Regrowth Testimony

   
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Lapwing

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August 13, 2011, 12:58 AM

Two people claiming to have gotten some unexpected hair regrowth from Pyrroloquinoline quinone (PQQ).

http://ask.lef.org/2422/Hair-Growth—-Simply-a-story

PQQ!  (Pyrroloquinoline quinone)  I just added this to my regimen a few days ago.  It seems like a pretty amazing supplement.  It hits just about everything, ie, conditions that correlate with hair loss.  It is pricey though.

From wikipedia:

Supplementation Benefits

PQQ is taken as a dietary supplement to support mitochondrial health, cellular energy production, and protect the body from oxidative stress. Most notably, PQQ stimulates the spontaneous growth of new mitochondria in aging cells, and activates genes that govern mitochondrial reproduction, protection, and repair.

[edit]Antioxidant Capacity and Role in Mitochondrial Health
Mitochondria are the primary engines of almost all bioenergy production in the human body and are among the most vulnerable physiological structures to destruction from oxidative damage. Scientists now recognize mitochondrial dysfunction as a key biomarker of aging. [13] [14][15][16][17][18]Relative to cellular DNA, mitochondrial DNA possesses few defenses against free radical damage, and is dependent upon antioxidants for protection. [19][20]PQQ’s powerful free radical–scavenging capacity provides the mitochondria with superior antioxidant protection due to its high molecular stability and the role it plays in energy transfer directly within the mitochondria. Unlike other antioxidants, the exceptional molecular stability of PQQ allows it to carry out thousands of electron transfers without undergoing molecular breakdown [21]

PQQ is especially effective in neutralizing superoxide and hydroxyl radicals,[22][23] two prominent causes of mitochondrial dysfunction.

According to a University of California at Davis study, “PQQ is 30 to 5,000 times more efficient in sustaining redox cycling (mitochondrial energy production) . . . than other common [antioxidant compounds], e.g. Ascorbic Acid (Vitamin C).”[24]

[edit]Mitochondrial Biogenesis
In 2010, researchers at the University of California at Davis released a peer-reviewed publication showing that PQQ’s critical role in growth and development stems from its unique ability to activate cell signaling pathways directly involved in cellular energy metabolism, development, and function.

Most significantly, the study demonstrated that PQQ not only protects mitochondria from oxidative stress—it promotes the spontaneous generation of new mitochondria within aging cells, a process known as mitochondrial biogenesis.[25] The implications of this revelation for human health and longevity are significant because the only other known methods proven to stimulate mitochondiral biogenesis in aging humans are intense aerobic exercise,[26] strict caloric restriction,[27] and certain medications such as thiazolidinediones[28] and the diabetes drug metformin.[29]

[edit]Activation of Signaling Molecules
The team of researchers at the University of California analyzed PQQ’s influence over cell signaling pathways involved in the generation of new mitochondria and found that there are three signaling molecules activated by PQQ that cause cells to undergo spontaneous mitochondrial biogenesis:[30]

PQQ activates expression of PCG-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a “master regulator” that mobilizes cells’ response to various external triggers. It directly stimulates genes that enhance mitochondrial and cellular respiration, growth, and reproduction. Its capacity to upregulate cellular metabolism at the genetic level favorably affects blood pressure, cholesterol and triglyceride breakdown, and the onset of obesity.[31]
PQQ triggers the CREB signaling protein (cAMP-response element-binding protein), which plays a pivotal role in embryonic development and growth. It also beneficially interacts with histones, molecular compounds shown to protect and repair cellular DNA.[32] CREB also stimulates the growth of new mitochondria.
PQQ regulates a recently discovered cell signaling protein called DJ-1. As with PCG-1α and CREB, DJ-1 is intrinsically involved in cell function and survival, has been shown to prevent cell death by combating intensive antioxidant stress,[33][34]and is of particular importance to brain health and function. DJ-1 damage and mutation have been conclusively linked to the onset of Parkinson’s disease and other neurological disorders.
[edit]Anti-Aging
The dual capacity of PQQ to act as both a cell signaling modulator and a powerful antioxidant renders PQQ supplementation a valuable front-line measure in preventative and regenerative anti-aging protocols, combating degenerative disease and age-related declines in the body’s most mitochondrial-dense organs—the heart and brain. Its ability to favorably affect system-wide cell development, metabolism, and mitochondrial biogenesis provide a wealth of neuroprotective and cardioprotective benefits.

[edit]Neuroprotection
PQQ is a potent neuroprotective nutrient that has been shown to protect memory and cognition in both aging animals and humans.[35][36] It has been shown to reverse cognitive impairment caused by chronic oxidative stress in pre-clinical models and improve performance on memory tests.[37] PQQ supplementation stimulates the production and release of nerve growth factor in cells that support neurons in the brain,[38] a possible explanation for the marked improvement of memory function it produces in aging humans and rats.

PQQ has also been shown to safeguard against the self-oxidation of the DJ-1 gene, an early step in the onset of Parkinson’s disease.[39]

PQQ protects brain cells against oxidative damage following ischemia-reperfusion injury—the inflammation and oxidative damage that result from the sudden return of blood and nutrients to tissues deprived of them by stroke.[40] Reactive nitrogen species (RNS) arise spontaneously following stroke and spinal cord injuries and impose severe stresses on damaged neurons, producing a significant proportion of subsequent long-term neurological damage.[41] PQQ suppresses RNS in experimentally induced strokes,[42] and provides additional protection following spinal cord injury by blocking inducible nitric oxide synthase (iNOS), a major source of RNS. [43]

In animal models, administration of PQQ immediately prior to induction of stroke significantly reduces the size of the damaged brain area.[44] These observations have been extended in vivo by showing that PQQ protects against the likelihood of severe stroke in an experimental animal model for stroke and brain hypoxia. [45]

PQQ interacts beneficially with the brain’s neurotransmitter systems. It protects neurons by modifying the N-Methyl-D-aspartate (NMDA) receptor site[46][47] and mediating excitotoxicity—the damaging consequence of long-term overstimulation of neurons that is associated with many neurodegenerative diseases and seizures. [48][49][50][51]

PQQ also protects the brain against neurotoxicity induced by other powerful toxins, including mercury[52](a suspected factor in the development of Alzheimer’s disease[53]) and oxidopamine[54] (a potent neurotoxin used by scientists to induce Parkinsonism in laboratory animals by destroying dopaminergic and noradrenergic neurons[55]).

PQQ prevents development of alpha-synuclein, a protein associated with Parkinson’s disease.[56] PQQ also protects nerve cells from the oxidizing ravages of the amyloid-beta protein linked with Alzheimer’s disease,[57] and works preventatively to block new amyloid beta molecular structures from forming before they can cause any damage.[58]

[edit]Cognition
PQQ has been shown to promote memory, attention, and cognition in animals[59] and humans.

In a double-blind, placebo-controlled clinical trial conducted in Japan in 2007, supplementation with 20 mg per day of PQQ resulted in improvements on tests of higher cognitive function in a group of 71 middle-aged and elderly people aged between 40-70, who outperformed the placebo group by more than twofold in their standardized memory tests. [60]

Interestingly, the results of the study also suggest a synergistic relationship between PQQ and the nutrient coenzyme Q10 (CoQ10), which further amplified performance on standardized memory tests when subjects also took 300 mg per day of CoQ10. No adverse effects were linked to the supplementation, and the results demonstrated that PQQ, especially when combined with CoQ10, can be used to improve mental status and quality of life in older patients, and help slow or prevent age-related cognitive decline in middle-age patients.

[edit]Cardioprotection
Damage from a heart attack, like a stroke, is inflicted via ischemia-reperfusion injury. Supplemental PQQ reduces the size of damaged areas in animal models of acute heart attack (myocardial infarction). Significantly, this occurs whether the supplement is given before or after the ischemic event itself, suggesting that supplementation within the first hours of medical response may offer profound benefits to heart attack victims.[61]

Researches at the University of California at San Francisco investigated this potential, comparing PQQ with the beta blocker metoprolol—a standard post-MI clinical treatment. Independently, both treatments reduced the size of the damaged damaged areas’ and protected against heart muscle dysfunction. When given together, the left ventricle’s pumping pressure was enhanced. The combination of PQQ with metoprolol also increased mitochondrial energy-producing functions—but the effect was modest compared with PQQ alone. Only PQQ favorably reduced lipid peroxidation. These results led the researches to conclude that “PQQ is superior to metoprolol in protecting mitochondria from ischemia/reperfusion oxidative damage.” [62]]

Subsequent research has also demonstrated that PQQ helps heart muscle cells resist acute oxidative stress by preserving and enhancing mitochondrial function. [63]

 

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# 1 ]

August 13, 2011, 04:03 PM

not to bad…

http://www.lef.org/Vitamins-Supplements/Item01500/PQQ-Caps-with-BioPQQ.html

 

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August 13, 2011, 07:38 PM

Nice one Lapwing.

I think I will give this a go..

 

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August 14, 2011, 09:03 AM

Lapwing…

Very interesting as I just ordered Co Q10 ubiquinol.  I do not see any mention of recommended dosage.  Do you happen to know what dosage was used in these studies?

Thanks.

 

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Lapwing

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August 14, 2011, 12:38 PM

Neutron,

I believe the standard doses are,
PQQ: 20-30 mg/day
CoQ10: 200-400 mg/day

I’ve been taking coq10 for some time at about 300 mg/day.  PQQ, I just started, and I plan to take 30 mg/day for the first month and back down to 20 mg/day after that.

 

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neutron

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August 14, 2011, 03:10 PM

Lapwing…

YOu take a pretty high dosage of CoQ10.  I went off the article on this website and took 50mg of Ubiquinol.  Are you taking this kind of ubiquone? Apparently Ubiguinol is more potent and that seems to be what they based the dosage on in that article.  Im really interested in this product.  I’d definately like to give it a try.  Maybe we should all monitor for 3-6 months since there seems to be 3-4 of us that are interested.

 

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scottyc33

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August 15, 2011, 09:10 PM

I am going to try this too - I will give it a few months and see how it goes.

I currently take 50-100mg a day of Ubiquinol.

 

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The Zix Creator

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August 16, 2011, 08:04 PM

I’d be careful here. I’m not trying to “rain on anyone’s parade” but many of us have been through a lot of similar stories over the years. It kind of works like this:

Someone makes a positive comment about something…...then we dig up scientific rationale for the substance…........then everyone starts using it….........then many claim success…......then the testimonials taper off and eventually the treatment is forgotten. The cycle usually seems to takes about 1-2 years.

This substance sounds promising. I just recommend you protect yourself to a degree from a psychological perspective. Sorry to come off as a “kill joy”. I really hope the best for everyone who suffers from MPB.

 

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Lapwing

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August 20, 2011, 02:58 PM

Neutron,

I am taking Ubiquinone the “weaker” form at the moment.  I take Jarrows CoQ10 Q-absorb.  100-300 mg is the suggested dose for this form.

Zix,

I agree, I usually take new stuff with a feeling of rolling the dice as opposed to expecting a huge result.  I hope for a good result, but my experience has tempered my expectations as well.  My goods results from prior stuff (eg, lllt) are always at least 1/3 less than what I hoping for, within what I thought was a “reasonable” expectation, and it took about 3 times as long as well.  Still I see other guys who were/are on my level of hair loss and they keep getting way balder, while my hair is somewhat better.

 

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Lapwing

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August 23, 2011, 12:06 PM

PQQ, an early follow-up.  I have been taking this for 2 weeks now, and I feel much more energetic and younger.  Maybe it is all psychological but I distinctly feel more vigorous.  It is like a couple of layers of fog have been removed.  Now if this can only translate into 10% more hair in the next 6-12 months…

 

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J87

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August 24, 2011, 12:26 AM

Eventually I might make a topical with this.

 

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HopeforHair

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August 24, 2011, 10:24 AM

I would like to test this—does anybody know a good source to order from?Does anybody know a european source maybe?German customs are like nazis so I’m hesitant to order it straight from the US because odds are customs are gonna keep it….

 

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neutron

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September 24, 2011, 08:58 PM

Hello Lapwing…


How is the PQQ coming?  What brand did you end up using?


Thanks.

 

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neutron

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September 24, 2011, 08:58 PM

Hello Lapwing…


How is the PQQ coming?  What brand did you end up using?


Thanks.

 

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Lapwing

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September 25, 2011, 01:47 PM

Neutron,

It is going good so far.  I seem to feel better on it and my weak temple areas seem more fuzzier.  It is hard to tell though if there is any additional positive hair effect yet.  The brand I got is Life Extension.  I don’t know if it is PQQ related but I got a hair compliment from a nice looking woman a few days ago.  It is so sweet to get a hair compliment these days.

I also recently started doing a more real scalp massage daily.  I think it is real important to get your scalp real pliable again for best chances of regrowth.  It is easy and it costs nothing.  Go to youtube and lookup scalp massage for techniques.  You want a soft layer of fat there instead of tight fibrotic calcified scar tissue.  I think the new thought is fat cells help signal the hair follicle stem cells to grow/regenerate or something like that.  I am not sure if the massage will posit more fat in your scalp but at least it may break up some of the scar tissue and free up some more hair follicle for regrowth.

 

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September 25, 2011, 02:31 PM

Lapwing.  Thanks for the update.  I’m thinking of giving PQQ a go myself.  Also, the scalp massages are interesting even if just for a stress reducer.  I tend to have a tight scalp due to stress so Im sure the massages would be a major relief.  I would think the increased blood flow should help.  Alot of people seem to due the massage in the shower while shampooing.  I can see why as the poors are all open and scalp is loose.  I will have to check out some of the techniques on you tube.  Im also going to take a look at life extension’s PQQ.

 

 

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Lapwing

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September 25, 2011, 11:50 PM

Neutron, I do it when shampooing.  The one thing I was doing wrong was just concentrating on the top of the scalp where I have hair loss.  It is important to really massage the muscles around the ears and occipitals in the back of the head.  The sides and back of the scalp are supposedly very important and I was overlooking them.

 

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KMD

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May 13, 2013, 12:16 AM

I’ve been using a 450 diode helmet (3 x times week) for more than a year and have had little or no positive results.  I am clinging to the hope that the magic starts after a year as OMG has said in one of his posts, but I’m doubtful.  I also use Regenepure and Promox.

So I’ve decided to focus on diet & exercise and I’m also thinking about ordering some PQQ, has there been any success out there with PQQ?

 

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Lapwing

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June 07, 2013, 08:20 PM

KMD,

I am still using PQQ.  Can’t say if there was any real hair benefit.  I still take it mostly for the energy and mental clarity it seems to give me.  If your hair loss has halted then that is a victory.  Keep as much hair as you can and maybe some day there will be a regrowth breakthrough.  My hair is maybe slightly better than last year.  I halted my hair loss and got modest regrowth.

 

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June 08, 2013, 05:07 AM

Thanks for the reply Lapwing.

Unfortunately by positive results I mean halting hair loss…I have significantly less hair now than a year ago and i have been shedding a lot in the last 4 months in particular.  I haven’t changed my regime in that time apart from adding decalcify capsules. I am on fin, Promox and a combination of regenepure shampoo and ortho organics shampoo. I’m 35 and exercise regularly and have very little stress in my life….so I really don’t know why i haven’t halted my hairloss (my hairline is regressing badly now and thinning all over) like I said i hope I’m shedding and there is some regrowth on the horizon but I’m beginning to doubt this.

Any advise is appreciated.

 

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Lapwing

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June 08, 2013, 10:46 PM

KMD, 

Wow, if you can’t beat hair loss with fin, lllt, diet, exercise, and low stress then I am not sure how to advise.  My only other advice is just to accept that all you can do is slow it down.  Don’t become a hair loss invalid.  In a way I did.  Life is short, enjoy and enrich yourself in other ways.  It is just hair.  Style your hair some way that you find acceptable and live your life. 

I have given up hope that they will have regrowth cure anytime soon.  I know how you feel, I love having hair and it sucks not to have great hair.  I am lucky that I still have a decent amount of hair, but I lost a lot of time fighting for it.  Probably would serve myself much better in retrospect by just getting a good woman and a dog and not worrying about my hair so much.  At least I cleaned up my diet and health a lot.

 

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