endogenous vs exogenous supplements
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New Member Total Posts: 1 Member Since: |
February 21, 2010, 06:23 AM Hi guys, Stoked I found this site…I wondered where OMG, Nid, JDP etc had got too :) Anyway I read this article at the below link. Basic premise is when we take supplements that are not found either in our bodies or in common foods (exogenous) - you can only them for about 6 months before they become ineffective. Any thoughts on this? http://www.youngagain.org/articles/article_what_does_endogenous_mean.htm When we take supplements that are found naturally either in our bodies or in common foods these are called “endogenous”. You can take such supplements for the rest of your life. All natural hormones are, of course, endogenous. This would include testosterone, pregnenolone, DHEA, melatonin, estradiol, estrone, estriol, T3, T4, progesterone, growth hormone, androstenedione and (human) insulin. When we take supplements that are not found either in our bodies or in common foods they are called “exogenous”. You can only take these for about 6 months, and maybe up to 12 months, and then will no longer work for you. Nearly all medicinal herbs are exogenous. Some examples of endogenous supplements that we can literally take for the rest of our lives would also include all vitamins and minerals since these are found in common foods. There are only 13 vitamins and about two dozen minerals we are known to need. Some supplements that are endogenous would include beta-sitosterol, beta glucan, quercitin, soy isoflavones, food enzymes, indole-3-carbinol or DIM, FOS, acidophilus, glucosamine, PS (phosphatidylserine), L-carnitine, L-glutamine, acetyl-L-carnitine and most any normal amino acid found in foods, flax oil, glutathione or N-acetyl-cysteine, lecithin, garlic, CoQ10 and SOD (superoxide dismutase which, unfortunately, is orally ineffective). You can take these for the rest of your life if you want to. It is a good question which culinary herbs such as thyme, rosemary, cumin, nutmeg, parsley, oregano, basil, cloves, ginger, horseradish, caraway, mint, etc. would be considered endogenous since they vary so much by culture and climate. Some supplements which are exogenous would include nearly any medicinal herb. This would include Gingko biloba, boswellin, milk thistle, ginseng, nettles, golden seal, barberry, aloe vera, black walnut (ellagic acid), coltsfoot, fenugreek, tumeric (curcumin), mugwort, chaste tree, sarsaparilla, and others. My experience has shown that after about six months of regular use they simply are no longer effective and you are wasting your time and money. In fact, you will often find a negative side effect if you keep using an exogenous supplement, such as a laxative or other effect. Curcumin, for example, is a fine and proven supplement but you simply cannot keep taking it year after year as it will not be helping you any more. If you want to know which supplements are SCIENTIFICALLY PROVEN to be effective, please go to the “ARCHIVES” and type in “supplements”. You will find at least three articles listing the supplements anyone over the age of 40 should consider taking for optimum health and longevity- that means over 20 supplements a day. You can also read my book “Zen Macrobiotics for Americans”, men can read “The Natural Prostate Cure”, and women can read “No More Horse Estrogen!”. You will be infinitely better off spending a hundred dollars or more every month for these proven natural supplements and hormones than you will for an overpriced health insurance plan. Health plans only help you symptomatically after the fact. PREVENTION IS YOUR BEST PROTECTION and not some after-the-fact hospitalization coverage you pay too much for. Please remember that “diet is everything” and no amount of supplements and hormones will ever make up for a poor diet. Please read my American macrobiotic book and start eating whole grains, beans, vegetables, local fruits, salads, soups- and seafood if you don’t want to be a vegetarian. Good diet is everything; just make better food choices.
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Member Total Posts: 39 Member Since: |
[ # 1 ] February 21, 2010, 07:41 AM all i have to say, after reading that article yrs ago, is that roger mason is half bald, so i don’t think his word means that much. his ‘hair again’, creme claims to be the most advanced treatment, but even though the ingrediants look good, theres no proof of results, and you’d think if it would work on anybody, he’d be using it on himself. exogenous vs endogenous is a good argument for healthy supplements, and prevention of disease, for e.g exogenous chemicals used to kill bacteria, fungus, and cancer is a huge problem, bacteria grows resistant to exogenous chemicals, and chemo therapy works less and less each round, making the doctors alternate medications, but mpb is not a disease, its a natural process (for most, not all) thats just been made worse by lifestyle choices , and requires unnatural treatment. mpb is not really the problem, its societies expectation of how we should look, that is the problem. by this i dont mean it should be synthetic over natural, but it should be exogenous, or at least interfere with endogenous processes. His main argument is about tolerance, and homeostasis, that is when u use an exogenous product, the body will eventually compensate to maintain normality, so he argues any exogenous chemical may work, but will eventually become pointless, this is seen to some degree with finasteride, although someone is likely still better off than they would be , even if they still return to baseline. (regarding hair only, obviously when u take sides into account, it sux) endogenous supplments may reduce the progression of mpb down to a normal level, but to stop it completely will have to be a foreign chemical to the body or exogenous chemical. be it natural or synthetic, herb or pharmaceutical, its still exogenous, if it wasn’t in the body to begin with. however there is a possibility that using an endogenous chemical or process may end up being the best treatment. stemcells are obviously natural to the body, but to use them topically on the scalp is an un natural process. but who wants to mess around with stemcells, until they get some decent studies done. Roger mason would probably argue that even stemcells in the scalp would eventually get overridden by the bodies ability to carry out genetically programmed processes, to maintain homeostasis. IMO even if u take a new baby with perfect health and a healthy mother, and keep them in the most perfect natural environment eating perfect foods, if their genetics say they will go bald, then they will, allbeit much much later than the rest of us who have made it worse with diet etc, and it will require a un-natural exogenous treatment to stop it, or to change gene expression. but i do think a hell of alot of mpb sufferers have made a pre-existing genetic programming 10 times worse by their lifestyle, first u need to fix the lifestyle, then do something to change the gene expression that gave u the predisposition, then regrow that hair. I’d be really impressed if someone could do that with all endogenous chemicals. roger mason looks like a quack, read through his list of supplements he sells, and read his comments about them. heres a few e.gs
2 top supplements he just calls scams, i dont know about resveratrol other than it being a top choice for some ppl here, but i know chlorella changed my life, and is a top supplment as long as the cells are cracked, but he thinks it sux as well. I just dont trust this guy. just my opinion of course. |
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Editor Total Posts: 351 Member Since: |
[ # 2 ] February 22, 2010, 02:17 PM Roger Mason is someone that I really do not have any respect for to be honest. He’s not trustworthy and as Anxious pointed out, his claims are absurd. While his argument against exogeneous supplements actually sounds good on paper (the whole homeostasis thing), it simply goes against reality. Taking a drug or herb that exhibits inhibition of a particular enzyme while continue to inhibit it…you don’t develop an immunity. It will continue to inhibit that enzyme. That’s like saying that if you hold a match to a particular spot of your arm for 6 months for the same amount of time each day, that eventually you’ll develop an immunity to that flame in that particular spot. I just don’t buy what he’s selling…figuratively, and literally. |
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Editor Total Posts: 81 Member Since: |
[ # 4 ] February 23, 2010, 07:10 PM Roger Mason has made a lot of bold assumptions over the years, most of which have turned out to be false. Taking EGCG (green tea) has benefits when taking beyond six months, just to mention one of many.
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Member Total Posts: 39 Member Since: |
[ # 5 ] February 24, 2010, 04:31 AM my experience with chlorella, is from when i got a hair analysis and had high levels of mercury , lead etc, from yrs of amalgam fillings, working in toxic factories, or possible inhalation of powder from exploding fluorescent tubes, any of which could have caused me the problem, but ill never know which one was the problem. to put it bluntly, i couldnt sleep, had several health problems, particually nerve problems such as restless legs at nighttime, sciatica, etc, and hairloss, and skin problems, and mental problems like depression and foggy thought. i did a detox with oral glutathione and 18 grams twice daily of chlorella, (only for a few months then i dropped down to 3 grams) and experienced an increase in these symptoms, then after a month they all went away completely, and everything came right, no more nerve problems, a great reduction in acute migraines, (with auras, and paralysis) no more restless leg syndrome, better sleep, but most importantly an amazing clarity of thought, that took me from working in crap factory jobs, to where i am now, which is halfway through a medical science degree, considering i failed high school, and am now holding my own against the smartest kids that will become doctors (regardless of ur views on conventional medicine, im sure u will agree, its very hard to become a doctor), i’ve surprised even myself, and with regards to hairloss, well bad shedding has gone, and now im just facing the more difficult, but slower problem of mpb, and seborraic dermititis, which could be the cause, or just a contributing factor. chlorella, apart from being a great natural balanced multivitamin, (as its one of the first life forms in the ocean, apart from bacteria), and having high chloraphyl (wrong spelling) when the cells are cracked with high temperatures, or radiation or something, they become great at picking up heavy metals to be excreted. Not to mention it makes good bacteria proliferate faster, for better digestion, i dont have a bad thing to say about it. It doesnt do it all, and there are better supplements around, but its still a top choice. Some ppl might say all of those things were due to the glutathione, thats something i cannot prove to be wrong, but i think they work better in synergy. And there are plenty of people who would agree. roger mason is a nutcase from what i can tell. |











