New Protein Identified in Study

   
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Corleone

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March 21, 2012, 02:01 PM

This story has been circulating today…thought it was interesting.  Below are links to a couple of the articles.

http://www.businessweek.com/news/2012-03-21/baldness-protein-identified-in-study-that-may-lead-to-treatments

http://www.medpagetoday.com/Dermatology/GeneralDermatology/31755

 

IGNORE

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# 1 ]

March 21, 2012, 11:36 PM

Ok, so it’s time to get prostaglandin D2 blocker.

 

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mj

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# 2 ]

March 22, 2012, 06:24 AM

just did a quick google search on this….sounds like niacin is bad to use if this is true.  According to an article on a niacin based merck drug that was blocked recently by the FDA, niacin causes prostaglandin to increase.  No mention of whether this was prostaglandin d2, it just said prostaglandin.

http://www.businessweek.com/bwdaily/dnflash/content/apr2008/db20080429_182260.htm


Tried a lot of things, never stuck with anything. Don’t do that

 

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BSD

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# 3 ]

March 22, 2012, 01:11 PM

http://www.elmhurst.edu/~chm/vchembook/555prostagland.html


Sounds like there are several types of prostaglandins with D2 being one of them. It could be that prostaglandin is just a symptom or response to inflammation, not the cause of hair loss.

 

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Lapwing

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# 4 ]

March 22, 2012, 01:50 PM

mj,

It is PGD2 that Niacin releases.

“Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR, as well as CRTH2.[1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, basophils. In mammalian organs, large amounts of PGD2 are found in the brain, in mast cells and found nowhere else. It is critical to development of allergic diseases such as asthma.

Research carried out in 1989[3] found that PGD2 is the primary mediator of vasodilation (the “niacin flush”) after ingestion of niacin (nicotinic acid).”

It looks like a topical niacin is a very bad idea!  Thankfully I never tried it.  The good thing is a topical PGD2 blocker should be on the way now in a couple of years.  From what I gather any anti-inflammatory stuff should be good for suppressing PGD2 to some extent.

 

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OverMachoGrande

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# 5 ]

March 22, 2012, 02:19 PM

Yet niacin is pretty well documented for HELPING hair loss sufferers.  I wouldn’t put any negative karma on niacin just yet, people.


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Lapwing

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# 6 ]

March 22, 2012, 04:42 PM

OMG,

I think niacin is remarkably UNDOCUMENTED to be a proven helper in MPB.  Positive anecdotal reports from a few individuals were probably the result of an overall good routine that could withstand and overcome the negative effects of niacin.  Certainly we all need some niacin, but to topical apply and take extra supplements of niacin in light of this new knowledge would be folly.  I never like the niacin flush and now I feel totally justified in steering clear of adding extra niacin to my routine. 

Update: I found one study that topical niacin was beneficial for women with alopecia areata.  Unfortunately what works for female AA does not usually work well for AGA(MPB).  Topical niacin is going to dump a lot unwanted PGD2 into your scalp.  That can’t be good.  Still if anybody has got any studies of niacin working against MPB I would like to see them.  I can’t find any in my short search.

 

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BSD

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# 7 ]

March 23, 2012, 02:12 AM

This finding was a part of a study for testing   http://en.wikipedia.org/wiki/Laropiprant

That says “Taking 650 mg of aspirin 20–30 minutes prior to taking niacin has also been proven to prevent flushing in 90% of patients, presumably by suppressing prostaglandin synthesis”

So according to this theory, shouldn’t a simple aspirin stop hair loss?

 

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Lapwing

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# 8 ]

March 23, 2012, 11:52 AM

BSD,

The problem with the aspirin theory is that many older guys for decades now take aspirin daily for blood thinning etc and I haven’t heard any stories from these guys saying “hey I started taking aspirin and my hair loss stop and my hair is looking thicker”.  If it was really true the internet would be flooded with these anecdotal stories. 

Personally I think aspirin will help somewhat, but I think nsaids are bad in general for the long run.  I think it is better to attack inflammation with more natural supplements and eating a clean diet.  So an anti-inflammatory style diet along with supplements should help with hair loss.

 

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Rosariorose9

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# 9 ]

March 23, 2012, 04:31 PM

BSD - March 23, 2012, 02:12 AM

This finding was a part of a study for testing   http://en.wikipedia.org/wiki/Laropiprant

That says “Taking 650 mg of aspirin 20–30 minutes prior to taking niacin has also been proven to prevent flushing in 90% of patients, presumably by suppressing prostaglandin synthesis”

So according to this theory, shouldn’t a simple aspirin stop hair loss?

Hmmmm.  Might it be worth trying a topically applied aspirin, like Aspercreme??

 

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