Wounding Protocol for Hair Loss
  Editor Total Posts: 510 Member Since: |
January 11, 2010, 11:09 PM Quite a few hair loss forums over the past couple of years have taken quite an interest in the Follica patent, and other similar processes (I believe Intercytex being another). Essentially, Follica found that hair follicles are “resettable” stem cells, and set out to accomplish this through a multi-tiered process. The first step was to remove the first layer of skin on the scalp (the “strata corneum”), the second was to apply an EGFR-inhibitor (Epidermial Growth Factor), and the third and final step was to utilize an agent that promoted WNT-signalling. Here is a link to the Follica patent: http://www.wipo.int/pctdb/en/wo.jsp?wo=2006105109&IA=WO2006105109&DISPLAY=DESC Here is the latest Follica news: http://www.follicabio.com/content/news/ The below instructions can, potentially, replicate this process out of the comfort of your home, without having to wait around for FDA-approval 20 years down the road (coupled with some insane price tag…). There are, of course, no guarantees, and this advice is for your entertainment only. Step 1 Utilize a TCA20 chemical peel. I purchased mine from the following website, direct link: http://www.makeupartistschoice.com/products/21_TCA_Kits-334-17.html If interested, here is some feedback that folks have given regarding how it feels to apply it on your face: http://www.essentialdayspa.com/forum/viewthread.php?tid=16556 Instructions will come with the peel, but I’ve seen folks around the hair loss forums recommend that you apply FOUR or FIVE layers for the area of the scalp that you wish to attain regrowth. From what I recollect, you apply one layer, wait five minutes for it to “frost” over, then you’ll be ready to apply the next. Step 2 The Follica patent called for an EGFR-inhibitor, and while there are some natural EGFR-inhibitors, I have not heard of anything good or bad about them. Thus, it may be safer to stick with a pharmaceutical as the patent recommends. This will require some knowledge of compounding, which I will attempt to step you through. First, we need to get ourselves some Getfitinib or Erlotinib. These are drugs that are experimentally used to fight some forms of cancer by acting as inhibitors of Epidermial Growth Factor. However, they are MIGHTY pricey, therefore we have to consider China and India generics for the experiment. In order to find a source, I would suggest becoming a member (easy and free) of the following online trade organizations: Once signed up, simply run a search query for “getfitinib” and you’ll get a ton of results. Start sending brief e-mail messages asking what they would charge for a few grams of the drug, and hope that they’ll respond! Once you acquire your getfitinib, you will want to put it in solution. I would recommend a 1% solution of Distilled Water and Getfitinib, and you can optionally use a little DMSO or DMI for enhanced absorption. Find yourself some 4 oz. amber bottles with droppers on the net for a few dollars as well. How to Compound into Solution Four ounces = 113.4g, so 1% of 113.4g = 1.1g You should be using 1.1g of Getfitinib if you wish to have a 1% solution. The remaining amount can be distilled water, or you can add a little DMSO (perhaps 5% of total solution) or DMI (perhaps 8% of total solution) for enhanced absorption to the hair follicle. This may not be necessary NOR desired, so do realize that using absorption agents may not beneficial. You can find DMSO for sale all over the web, but I’d recommend http://www.bulkactives.com for DMI, as it’s a tougher find. You’ll want to weigh out the Getfitinib on a scale, and if you do not have a scale, you should be able to find small and reasonably-priced digital scales around the net fairly easily. After that, you’d simply mix it into solution with the Distilled water, and then pour it into your 4 oz. amber bottle. Step 3 Now, you’ll need an agent that promotes WNT signaling in your hair follicles. One possible candidate is Lithium Chloride. You can purchase Lithium Chloride fairly easily as it is not considered a drug. Here is one possible source: http://secure.sciencecompany.com/Lithium-Chloride-100g-P6357C670.aspx You will have to follow the same compounding instructions as above, however, the percentage that you decide to use in this formulation is up to you. You could try 1%, 2%, 5%, or 8%, and you may or may not wish to use some DMSO or DMI in the mixture. This choice is entirely yours. Remember that more isn’t necessarily better when it comes to compounding. Distilled Water will, again, be your primary ingredient in this formulation. PROTOCOL The basic protocol that I’ve derived from the Follica patent and the research of others over the past couple of years is as follows: 1) Wounding (with chemical peel in this instance) - Wait 2 or 3 days 2) Apply your EGFR-inhibitor 2 or 3 times daily on wounded areas. Do this for 7 to 10 days. 3) Apply your WNT-signaller twice daily. Do this for 20 to 30 days. At the end of this process, you may (hopefully) observe new hair growth. If you have any questions on the process, drop them here, and I’ll try to answer them to the best of my ability!! NOTE: This is by now means a comprehensive interpretation of the Follica patent, and many possibilities and various combos for this procedure are hinted at in the patent that are, in my opinion, worth investigating. |
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Editor Total Posts: 510 Member Since: |
[ # 2 ] January 17, 2010, 06:40 PM When I did this, I made the mistake of only doing one layer with the TCA20 chemical skin peel, so my results were “nerfed” (diminished). From what I’ve read from other forumers around the net, a good 5 layers is optimal. Still, I managed to get a few vellous hairs going and a couple of those went terminal, but nothing amazing. If you’re not afraid of being bald for a little while, I’d recommend shaving down with a “1” guard on your electric razor, and then waxing your entire scalp. Wait 2-3 days, then apply 5 layers all over your areas that you want to grow hair on. Then, follow the above protocol. I don’t have the study off-hand, but apparently waxing greatly augmented the amount of hair follicles formed! |
 Member Total Posts: 64 Member Since: |
[ # 7 ] June 25, 2010, 06:52 PM I’ve decided to give something like this in the near future, but I’m going to incorporate iodine. I have been applying lugols to my hairline for a few weeks now, and I think that the kind of regeneration seen in the Derry studies may need some kind of substantial damage to create such a dramatic regeneration effect. In any case, I plan on using silver nitrate sticks to cause a chemical burn, then painting the area with lugols after a scab forms. In this time I’ll cover the area in milk thistle extract (for the silymarin) and fresh garlic juice after x amount of days (because I’m out of lithium powder). Maybe the extra stem cell movement caused by the iodine will provide for more differentiation into hair follicle cells, maybe it won’t. Considering I already have everything but the silver nitrate sticks (they’re on the way), I guess it would not be too much a big deal to at least try. I have seen some amazing results with iodine on a few smaller scars over the last month, so I am more than convinced of its regenerative properties. Hopefully that’ll translate into hair regrowth at my hairline, but considering it is so cheap, there’s not much lost if nothing works. |
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Member Total Posts: 64 Member Since: |
[ # 10 ] June 26, 2010, 08:20 PM I am, recently started using it on my crown as well. I’m not sure if I like it more than straight lugols, though. Putting straight lugols gives me that burning sensation and the skin peels off a few days later the way it does in Dr. Derry’s pictures. When I use the DMSO mix, I dont really get any burning, and it doesn’t create that thick red/brown skin that peels off. Instead, the color fades really quickly, and the skin that peels off is thin and normal skin colored. I don’t know if this is because it’s more dilute with the DMSO in it, if it is absorbing too deep to cause the snake skin (or right into my bloodstream and bypassing the skin altogether), and I have no clue if it is working better than the straight lugols or worse. I plan on sticking with it for a while because it does wonders for inflammation, hopefully I’ll have a better idea of what works best in 3 or 4 months time. on a side note, I’d love to get my hands on some of that 7% lugols they sell in the UK. Wouldn’t have to worry much about dilution then. |
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Editor Total Posts: 168 Member Since: |
[ # 11 ] June 26, 2010, 08:37 PM Thanks FunkyStumpfighter. I appreciate it. I don’t really visit hair loss forums anymore as Rife is more than I could have ever expected but I always keep my eye open for regrowth. FWIW, it’s hard to tell and could be wrong but combining LLLT and Lugol’s may cause increased skin shedding than using straight Lugol’s 2% alone. What I mean is it seems that when I use LLLT the day after I get really nice thick skin shedding… flakes comparable to a sunburn. When I’ve used straight 2% I get thin pieces. Again, could be wrong but something to try. |
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Editor Total Posts: 168 Member Since: |
[ # 12 ] June 26, 2010, 08:42 PM BTW, that 7% Lugol’s really isn’t 7%. |
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Member Total Posts: 64 Member Since: |
[ # 13 ] June 26, 2010, 08:52 PM Not a problem. Man, I get that kind of peeling every time I apply straight 2%. I usually apply it twice though, letting it dry once, and applying another coat on top. Usually by the third day I’m peeling in sheets inches long, its an odd sight, and not one I’d want people to see (usually my hair hides it). I really need to get my diodes replaced (they’re of the burning hot variety), but I’d like to be able to buy 50 more before I send the ones I have back to get replaced. Weirdly enough, I miss LLLT, though my blood irradiation setup works well enough to give me that uplifting full body surge to keep me from going into laser withdrawls. Ha, it was that exact thread that I found that 7% lugols. I probably should have read a bit more of it. |
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Editor Total Posts: 168 Member Since: |
[ # 14 ] June 26, 2010, 09:48 PM Easy to get them replaced! Not sure if things have changed but about 9 months ago called, said I had about 15 lasers go bad. Guy put me on hold for 2 minutes after getting my name and address and said he’d ship them right away. Didn’t ask for me to ship the dead ones back or anything. Granted, they may ask for you to ship back if you have a lot of lasers though. Who knows. |
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Editor Total Posts: 510 Member Since: |
[ # 17 ] July 09, 2010, 02:56 AM
Hey Socrates, I’ve heard that enzymes in general can work quite well. I guess what you’ll want to look into is the strength of each of these—too much would be a bad thing. Removing the first layer of skin is a painless and relatively easy thing to do. Do you have any examples of products that I can take a look at for you? |
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Member Total Posts: 25 Member Since: |
[ # 18 ] July 09, 2010, 05:20 AM Hey Nidhogge, What I had in mind was actually mixing some papain powder with emu oil or something, that would hopefully dissolve some of the scar tissue that obviusly has formed on my scalp after my period of aggressive inflammation. But I am a bit worried about my actual hair and hairfollicles with this topical. Perhpaps looking directly to Elsom topicals is the way to go. Do you have any experience with Elsom products ? OMG - you mentioned in the other thread that we should make a own thread about fibrosis and how to deal with it. This is in my experience a topic that is talked about a lot, but we dont have come up with any “aggressive” treatment protocols. Sure lasers does wonders, but this takes severel several months, even years for someone I guess. |
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Member Total Posts: 64 Member Since: |
[ # 19 ] July 09, 2010, 07:25 PM Anyway, back on topic. @Nid - I did a test patch on my stomach with 15% TCA, took maybe a good 4-5 coats before I saw any frosting (I didn’t clean the earea too well before hand, so that’s probably why). After it frosted, I applied another coat, and just let that sit. I haven’t seen any peeling at all, just a slight pinkness to the area. Is this what you saw? Is there supposed to be a shedding of the skin at some point, or does the peel just cause the skin to fall off like a dust? I have everything I need to try this out, but I’m giving it a few dry runs on other places before I put it on my head, just to get a feel for what to expect. This first trial really didn’t seem to do much of anything at all sans some pinkness. |
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Member Total Posts: 30 Member Since: |
[ # 21 ] July 28, 2011, 10:22 PM I’ve been using tca peels and been having some success. My last attempted was with a 21% peel with 4 layers. I’ve also posted more info under my fibrosis post. |
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