brh

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March 2010

March 17, 2010, 09:32 AM

IH What would you initially expect from taking curcumin?

Immortal Hair

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[ # 1 ]

March 17, 2010, 11:53 AM

brh - Experiences may differ of course in everyone, however there are some general expectations. First I should state that curcumin is more viable when it is combined with trans-resveratrol, but first will just discuss curcumin on its own.

While the focus in the medical literature discusses the relatively low absorption of curcumin in the serum,
I believe the positive effects exerted from curcumin do not manifest from entirely from a serum level, but begin during its interaction with the intestinal microflora.

Curcumin in small doses provides a hormesis effect, in which a relatively small dose exerts positive effects with respect to adaptive cellular stress response to activating signaling pathways that result in increased expression of genes encoding cytoprotective proteins including antioxidant enzymes, protein chaperones, growth factors and mitochondrial proteins.

Curcumin in larger doses appear to benefit the intestinal microflora, and shorten the bowel transit time, provided there is at least some turmeric in the curcumin fraction.

Generally, curcumin modulates the release of serotonin and dopamine in a positive manner even during elevated stress. So, it can act as an anti-depressant.

When curcumin is used along with EPA/DHA from Omega-3 fatty acids, it can significantly reduce inflammatory effects of iNOS, COX-2, 5-lipoxygenase (5-LOX) and cPLA(2).

When curcumin is taken with trans-resveratrol, an added benefit occurs with respect to neurogenic inflammation. Trans-resveratrol and curcumin act as antagonists/inverse agonists at CB1 receptors in low to moderate doses. Effectively, they reduce the sort of inflammation that occurs during heighten stress response and the temperature changes associated with skin. This is especially useful for the temporal area.

brh

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Total Posts: 84

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March 2010

[ # 2 ]

March 17, 2010, 01:07 PM

So then it would be ok to start taking saw palmetto while on circumin? Im taking EC as well. I didn’t know that the combined effect of cirumin and resveratrol acted differently. I just figured..anti oxidant=anti oxidant.

Immortal Hair

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[ # 3 ]

March 17, 2010, 01:28 PM

brh - A variety of substances increase the efficacy of curcumin, so yes adding resveratrol will expand its protection to a whole new and important area.

Saw Palmetto is not so predictable and to my mind and experience, it’s a lot like adding a Pinto to your automobile collection of Ferrari’s and Lamborghini’s.

I would suggest adding Sulforaphane instead of Saw Palmetto.

brh

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Total Posts: 84

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March 2010

[ # 4 ]

March 17, 2010, 03:23 PM

Icic…does Sulforaphane have DHT reducing properties?

brh

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Total Posts: 84

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March 2010

[ # 5 ]

March 17, 2010, 03:27 PM

Im thinking about adding something that slightly reduces DHT but not to the extent of propecia. Over a long peroid of time maybe it will slow loss.

Immortal Hair

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[ # 6 ]

March 17, 2010, 03:38 PM

brh - Curcumin inhibits DHT to an extent, and both curcumin and sulforaphane down-regulate and/or repress the expression of the androgen receptor. So, in other words, it renders it less sensitive.

brh

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Total Posts: 84

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March 2010

[ # 7 ]

March 17, 2010, 03:54 PM

Ok thanks IH

brh

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Total Posts: 84

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[ # 8 ]

March 19, 2010, 05:31 PM

Immortal, been reading up on Sulforaphane. The product with the link on your site basically says its a form of selenium. I have biosil. Isnt biosil basically selenium?

brh

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Total Posts: 84

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March 2010

[ # 9 ]

March 19, 2010, 05:36 PM

I see that it just has selenium with broccomax as well. Who do you recommend as one of the better supplement providers. As far as toxic metals in such. Thanks

Immortal Hair

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[ # 10 ]

March 19, 2010, 05:38 PM

brh - Are you asking what best metal chelators (detoxifiers) are?

brh

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March 2010

[ # 11 ]

March 19, 2010, 11:41 PM

No, I was asking what supplement brand is best regulated so that were not taking in toxic materials from the supplements that we are taking.

Nidhogge

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January 2010

[ # 12 ]

March 20, 2010, 02:33 PM

brh—

We will be releasing some products of our own, including an Eclonia Cava/Curcumin/Resveratrol supplement that will use pharmaceutical-grade ingredients, at therapeutic quantities.  It will be a bit yet, but something to keep in mind for a trustworthy source, as we will of course be using our own supplements!