The Mechanics of Male Pattern Baldness

Reposted from David M. Hatch, August 01st, 2010, 2:34 pm


Editor’s note:  This is a reprint from the article located at  All of the work was done by David Hatch, the owner of this website (and the artwork was done by Nathan Pitkin).  Efforts have been made to contact him to get him involved in the discussion, but since this has been up since 1997, we have no clue if he wants to participate or even can still be contacted at his given email address.

This theory, however, has great merit and offers some explanation of the “missing link” of hair loss (ex: the PATTERN of MPB, which to my knowledge hasn’t ever been fully explained), and we would like it talked about -and never forgotten if the website ever disappears.  Hopefully he will join us in the future -but the discussion shall continue regardless!

So, what we will do is post his article IN FULL, and then discuss it amongst ourselves below…



David M. Hatch

(Copyright, 1997-2010 David M. Hatch, All rights reserved.)

Thank you for your curiosity. Now lets see if I can maintain your interest. Being a layman, I was able to take a look at this condition known as Male Pattern Baldness without preconceived notions and yet, I lack the basics in both bio-mechanics and physics that the practitioners in those fields take for granted.

I guess the one thing that I have going for me in this case is, while ignorance may not be bliss, it protected me from the “We know everything there is to know about that area, so we never have to look there again”. So, for the time being, please give me the benefit of the doubt and walk with me through the sequence of observations that led to my conclusions.

One of the first things I realized was that we had handed this problem to the wrong people. It should have been given to the physicist, the mechanical engineer, the bio-physicist or the biomechanical engineer. Since it deals with the body, we asked the medical profession to address it. So far they haven’t gotten back to us yet with anything but sketchy results. Fiddling with DNA will be fine for future generations but what can we do today?

Bring this theory to the attention of any of the specialists mentioned above and they will instantly grasp the concept. Ask a medical person about Male Pattern Baldness and they will mentally consult all the data they have accumulated on the subject, but haven’t personally inspected, and not finding this theory there, will dismiss it.

So let’s see if there’s something we can do in the meantime about getting our hair back while the medicos unlock the secrets of the universe.

Alright, here we go. Let’s observe the obvious. Look at a head with male pattern baldness…In the mirror. As you might have guessed, I have a vested interest in the resolution of this amazingly introverting condition, hence, my acute and heart felt attention. At the age of eighteen, I noticed an abundance of short dark hairs at my hairline and didn’t know what to make of it. Then, not too long after that I noticed the crown receding and the temples cutting back sharply. Then the sickening realization that the hair on the entire top of my head was getting thinner. What was once extroverted attention, crashed back on me and all I could think about was my hair.

Let’s face it, the first thing that people notice about you is your gender and the next is your face and hair. The only thing that could distract that would be if you were on fire. “Well, he was on fire and had thinning hair”. That’s what a witness would say.

Men the world over from that moment of shocking realization to the desperate flight into dozens of topical remedies to wigs that fool no one to the hacking and hewing of surgery, millions of dollars have been spent. I believe the majority of “well adjusted” balding men who are “OK with it” might possibly be coaxed into saying that they wouldn’t mind having their hair back if it were possible. I believe that, like whisky and chewing tobacco, baldness is an acquired taste. I can’t imagine any young man in the entire world at the moment he realizes he’s losing his hair shouting with joy, “Hooray! I’m going bald!” No, I don’t think so. OK, with absolutely no evaluation at all, let’s look at what’s in front of us; let’s observe the obvious. Imagine a balding head rotating before you.

We see a circular area in the center of the back of the head where the hair is the thinnest or nonexistent in the exact center of the circle.

Next, in profile, we see a strip of hair that appears to separate the balding circle in the back of the head from the thinning or bald area at the temple and crown. Face on, we see the hair on the sides of the head the sharply defined “M” line of yesteryear or more advanced, a few sparse hairs at the crown possibly divided by a completely bald;section at the exact crest of the skull.

As the head turns, we see a repeat of the first profile. We observe that there is symmetry to this pattern;left and right are almost identical with slight variations. In the case of the very advanced baldness, we see a very sharply defined border of the hair on the back and sides of the head. In the back of the head, the bald area dips down; almost to where the head and neck come together. In almost all cases the skin of the scalp appears to be shiny. Figure 1
You know, I’m going to stop here for a moment and tell you what got me started investigating in this direction. What would cause the scalp to be shiny? By pulling it tight against the skull. It seems that the one thing that all the practitioners in their field of M.P.B. might grudgingly agree to is that the scalp can be tight. Why hasn’t anyone asked the question how can a scalp be tight and then proceed to look into it to see if there might be some connection? This made me wonder about the nature of stress. What is it?

I think I’ve come up with a tidy definition.

Stress is the resistance to or against something approaching, present; or departing. All things departing were once present and all things present were once approaching. Look at your own life, and every scenario can be distilled to this basic.

OK, do I hear the grinding of teeth?; A little too much of the obvious? Hang in there folks. Now our story takes an interesting turn. We now are going under the skin of the head. Where we stop is at the galea, that tendon like membrane that the scalp is bonded to. Here we see the bilateral symmetry (both left and right sides alike) of the small muscles that attach to the galea.

I’ve included an illustration from some anatomy books for credibility; but Nate Pitkins’ illustrations really communicate the situation.

As an aside, I was wondering what the galea and its attaching muscles were designed for. Possibly the pumping of spinal fluid prior to the hardening of the sutures of the skull?

But I’m drifting, ...back to the story.

Underneath the galea separated by a thin membrane we see the large muscles that close the jaw and that this muscle mass climbs quite a ways up each side of the skull. Interestingly, it appears that the front attachment of the galea to the muscles of the forehead looks surprisingly like the line of a normal hairline. In other words, the normal hairline follows exactly the line where the galea attaches to the muscles of the forehead.

In profile, we see the clamshell shaped muscles that attach the galea to the side of the head. Please note the shape of these muscles. They are fan shaped so that when contracting, they exert a pull across an area of almost 150 degrees. 

On the back of the head we see the two muscles attached to the galea exactly where the flat plates of the skull end and the sharply curved dome of the skull begins.

Also, of major importance to this theory are the muscles that attach to the back of the ear. In some people these muscles are under voluntary control and they can move their ears at will.

My theory, according to what I have been able to observe of the male pattern and the underlying structure of the galea, its muscle attachment points and the shape of the skull is this:

The scalp and its capillary bed are bonded to the galea, which actually floats over the skull and is only attached to the skull by the muscles described above. These muscles, for some reason, arrive in a state of continuous contraction. Because of the mirror image placement (left and right side) of these muscles, as they contract, they create a down force by tightening the galea/scalp unit against the curve of the skull sufficient to impede blood flow to the hair follicles.

If you were to remove the curve of the skull and could see the opposing attachment points across a flat surface, it would look exactly like the attachment and tightening points of a drumhead. Kind of makes me think of a reverse Eskimo blanket toss thing. Only instead of Eskimos twanging one of their fellows into the air, these muscles attached to the galea are trying to twang you into the ground and the only thing that happens is you lose your hair.

Let’s start with the fan shaped muscles on the sides of the head. When it contracts, it’s pulling along a 150-degree radius inward toward one point.

Well, on the opposite side is the mirror image muscle doing the exact same thing. When this tug of war is done over the curved surface of the skull, you get some interesting down force multiplication.

Let’s apply this theory to the pattern and see if it works. If you were to have two equal and opposite forces being applied across a curve, where would the force be greatest? At the exact center or highest point of the curve. Where does the bald spot start? At the center! As it grows, it radiates symmetrically. Why is it that when these muscles contract over the flat plates of the skull there is no hair loss? No curve, no down force, no blood flow impediment. You remember those muscles I mentioned earlier? The ones behind the ears that pull them back? Well, when those contract, guess where the slack gets taken up. Right, these amplify the down force exerted by the side muscles enormously.

Now let’s take a look at how the side muscles affect the crown of the head. Apparently, this kind of never ending muscular contraction is called Biological Tension. In the case of hair loss, it only has to be great enough to defeat the push of normal blood pressure. When that happens, no nutrients in and no waste out. The follicle starves to death.

Let’s go back to looking at the mechanics of the structure for a moment. Where the scalp/galea bond ends along the forehead, the fatty layer and capillary bed are at their thinnest.

To use an example, think of when you’ve climbed into a bed where the top sheet is very tight and your feet are taking positions you never thought they could. Where is this sheet tightest? At your feet where it curves down and under the mattress. Where is male pattern baldness usually first noticed? At the crown and temples. Let’s use the pattern itself to explain how the side muscles affect blood flow to the scalp. It’s interesting to note that in so many cases of M.P.B. at the crest of the skull there appears to be an area at the exact center where the hair is thinner or nonexistent and that is bordered on each side by hair that is a little thicker. This balder area is usually 1/4 to 3/4 inch in width.

Back to the example of the tight sheet but this time stick the hood of a ‘37 Buick with the nose toward the foot of the bed. Where is the sheet tightest? At the hood ornament! It appears that most skulls have this raised crest of bone and that introduces a higher elevation and a sharper curve and this multiplies the down force even more. Hence, less blood flow equals faster hair loss along the crest than along the bordering sides.

All right, let’s move on to those pesky muscles at the back of the head.

Now it’s interesting what happens when these muscles haul down on the galea. Because of the geometry of the skull, (some what egg shaped looking at it from the top) when the left side contracts, the resistance occurs where the galea attaches over the right eye and right temple. Vise versa for the right side. It’s interesting that these muscles pull back in an “X” configuration. Right back pulls left front, left back pulls right front.


Because of this cross pull on the scalp, and due to the topography of the skull sometimes you will see those little “islands” of hair at the crown of the head where the counter forces neutralize each other. (David Letterman).

Once again, back to the bed sheet analogy. The pull of the muscles on the back of the head squeezes the scalp down against the curve of the skull along the attaching line at the forehead and temples where the scalp is thinnest.

There’s one more thing that this theory explains. Why is there a strip of hair that seems to separate the bald spot in the back and the one on the crown like the band on headphones? The reason that this area is one of the last to go is because of the soft tissue of the jaw muscles gives under the compression of the scalp over them.

So as you can see, the combined pull of these six muscles creates a system of down force on the scalp that is perfectly balanced and quite complete.


What needs to be done is to release the scalp capillary bed from the constant down force generated by the muscles attached to the galea so that blood flow can be re-established to the whole scalp. The simplest and least invasive technique would be to inject those muscles [back of head, behind ear] with Botox used already to relax muscles between the eyes . Botox lasts only four to six months and severing the muscles surgically would be permanent. I recommend small vertical incisions over each muscle group and the horizontal cut done under the scalp.

A NOTE OF CAUTION (To the doctors who will perform this procedure): I do not recommend the use of Botox on the side muscles since they could not be injected without affecting the large jaw muscles that are just underneath them. All the other muscles [back of head, behind ear] are isolated and can be addressed safely.


Once the underlying scalp muscle tension is handled permanently, all the M.P.B. handlings that are on the market will explode with enhanced effectiveness in the re-establishment of the capillary bed of the scalp.


This theory and handling are specifically and exclusively focusing on the condition known as Male Pattern Baldness. So class, your homework assignment is to look at the balding heads around you and see how this theory might apply. It is my belief that this condition is caused only by the loss of blood flow to the hair follicles and if blood flow can be restored, then maybe the follicles could be encouraged to once again do what they do best.

Unfortunately, there is no way that I can patent this procedure and become a billionaire overnight, so please get it to the community of plastic surgeons so that they can make even more money.

The beauty of this theory is the simplicity with which it can be proved or disproved.

Both the Botox and the surgery are minimally invasive and at this point I would recommend that only the muscles behind the ears and back of the head be addressed for now.


Thank you for your time and attention, please feel free to contact to me with your thoughts on this theory.

I would like to thank and recommend the prodigiously talented Nathan Pitkin, the Jimi Hendrix of pen and ink for his amazing drawings that convey the concept better than any words.

Copyright, 1997-2010 David M. Hatch, all rights reserved.



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August 01st, 2010, 05:00 PM

I’ve always found this theory VERY INTRIGUING!  I’ve picked up a lot of anecdotal information over the years that has supported this, and I’ll try to bring it to this article at some point.

Obviously, it doesn’t explain away EVERYTHING with MPB, but I think of it as a piece of the puzzle.

Not only does this article describe how the “pattern” of MPB occurs, but it also describes the mechanism as to why Botox can work for hair loss.  Alleviating the downward tension caused by the muscles attached to the galea would divert the blood flow back to the capillaries, too, and keep other areas from “Bogarting” the blood supply. 

So, very interesting indeed!


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The Zix Creator

The Zix Creator


August 02nd, 2010, 03:26 PM

Well I don’t know.

First if this “tightness” and lack of blood flow is the main cause of baldness why can we take a hair follicle from the back of the head, transplant it, and it will continue to grow for the rest of ones life? We have not altered the vascularization of the tissue….we’ve simply put a genetically different follicle in it’s place.

So I think the ground rules for this discussion would start with us all assuming we are already speaking of “genetically challenged follicles”. Not “balding resistant follicles”.

Now that I’ve established that let’s first start with the drug propecia. We know this grows hair. Yet below is a study that shows propecia actually reduces vascularization to the tissue (blood flow). Yet propecia grows hair.

The conclusion of this study was the following:

“Decreased expression of VEGF by finasteride inhibits angiogenesis and significantly decreases microvessel density in prostatic suburethral tissue.”

I take this to mean “less blood flow” to the prostaic tissue. I don’t think it’s to far a jump to assume that it works the same way for hair follicle tissue as well.

Here’s another study that hints around that propecia reduces vascularization:

I find this the most interesting part of the article:

“Finasteride has been shown to reduce prostate bleeding in patients with benign prostatic hyperplasia (BPH). The mechanisms behind this are not known, but it has been suggested that finasteride reduces bleeding by inhibiting angiogenesis in the prostate.”

Ok so there were two studies that hint around that propecia actually reduces blood flow to at least prostate tissue. I don’t see why this would be different with skin and follicles as well.

Now the other side of the argument.

We do know there is a surgery perfomed in Belgium known as a galeatomy. A clinic that does this can be found here:

But they make no mention as to how or why the procedure is effective. Yet Belgium is not exactly a third world country. They are a nation of laws not unlike our own. So for the procedure to be allowed it seems to me there would have to be some efficacy to it. Yet on the other hand if the procedure works….why don’t they do the surgery in the U.S.?

So in short I don’t know what the hell to believe! LOL!





August 02nd, 2010, 03:56 PM

So in short I don’t know what the hell to believe! LOL!

I know, right?!  lol…

The only answer that I can possibly see as the logical answer is that BOTH are correct.  If ONLY what Merck said was true, or if ONLY what the article and the Belgium place said was true, hair loss would be solved!  It’s not… it’s proved to be an extremely difficult, complex BEAST.  Yet, sometimes (at least the marketing would have us believe) doing just ONE of those things will work for someone.

So, to repeat myself, the only logical thing to deduce is that hair loss is a large, complex spider web -and everyone has a different “level of efficacy” for each individual string in that web, which makes one thing work for somebody yet ineffective for someone else.

We can make the argument that this may mean that there isn’t ever going to be ONE, ALL ENCOMPASSING CURE.  However, nailing each string of the web as best as you can with a regimen that focuses on all of your particular strings that you can identify has been working for quite some time now for many, many people, so at least that’s some good news for a change! 


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Immortal Hair

Immortal Hair


August 02nd, 2010, 07:18 PM

In the 90’s I stumbled on a book about hair that had this whole theory of the galea in mind.

I didn’t know what to think about it, and I still have reservations about it.

This study here below, originally posted on my natural hair regrowth forum is very interesting I think.


To the Editor:\p=m-\Some questions concerning baldness which
were raised by Dr. Ballenger’s comments in The Journal,
June 27, may be answered by observations which I made
while serving as technician in gross anatomy at the College of
Medicine of the University of Illinois (1916-1917). I then had
occasion to remove the brains of about 80 cadavers for separate
use in the neurology classes and incidentally noted a seemingly
obvious relation between the blood (vessel) supply to the scalp
and the quantity of hair. Baldness occurred in persons in whom
calcification of the skull bones apparently had not only firmly
knitted the cranial sutures but also closed or narrowed various
small foramens through which blood vessels pass, most prominently
in persons with a luxuriant crop of hair. These blood
vessels are mainly veins which normally communicate with the
diploic veins in the spongy tissue of the skull bones but which
are evidently pinched off by calification of the foramens. Various
stages of this process of impairing the blood circulation of
the scalp could be observed.This, then, not only explains why baldness occurs but also why men are more likely to become bald than women, since
bone growth or calcification is generally greater in males than
in females. Obviously “hair tonics” or vitamins are not likely to
restore a blood circulation through what has practically become
“solid ivory.” Moreover, one wonders whether the promotion
of a higher calcium intake among adults may not eventually
increase the incidence of baldness and the sales of its vaunted

So if this observation is true, and I believe that it is, calcification will inhibit the passage of blood flow through the diploic veins that reach through the foramen that travel to scalp skin.  I think of vascular health here, especially with respect to a nutrient severely lacking in many diets, vitamin K2 that is.

Vitamins K2 & D3 work synergistically to remove calcification of the vascular system. And if there is enough magnesium, it will also help keep calcium in solution instead of deposition.  Vitamin K2 will keep the vascular system more elastic also.

There are other factors that maintain calcium homeostasis also, but the ones above are the primary.


Now available for consultation (hair and/or health)

The Zix Creator

The Zix Creator


August 03rd, 2010, 12:40 AM

Hi IH.

But then why can we take a hair follicle from the back of the head, transplant it to the front and it will grow forever? We are supposedly transferring it to an area with less blood flow. Or are you speaking only of the “genetically challenged” follicles?

To really test your theory we would have to transfer a hair we know is going to fall out (like at the hairline of a balding person) to the back of the scalp. Then see what will happen to this follicle. Will it gradually stop producing a terminal hair?

Do we have any studies that have tried this that you are aware of?

The Zix Creator

The Zix Creator


August 03rd, 2010, 05:18 AM

I was doing some searching around on another forum. Suffice it to say they have actually taken hair follicles that were predicted to miniaturize and transplanted them to areas where no balding was occuring. These follicles miniaturized on a predictable schedule. I hope to soon have a study to back this up.

To me this blows the whole “blood flow is good theory” completely out of the water. If I get a study to back this idea up it will finally at least satisfy my curiosity on the subject. It will finally convince me that improving blood flow will not help the balding person.

Knowing what won’t work is a step forward toward figuring out what will work. I still believe it might be advantageous to reduce blood flow in the scalp. Reducing blood flow would be how we reduce inflammation. Using a topical astringent thereby reducing blood flow and inflammation may be of benefit. Something like black tea in the right concentration. We might even get a “twofor”. Black tea taken orally was shown to reduce DHT….perhaps it would do this topically as well? The tannic acid in black tea would serve as an astringent, reducing inflammation.

Tannic acid is an old nursing trick. If you have a patient that had a tooth pulled and it won’t stop bleeding you put a tea bag on the site for a few minutes. Presto…the bleeding stops.

So in humble opinion, if relieving this “tightening”, does in fact help with MPB then it works by a mechanism not related to blood flow.

Immortal Hair

Immortal Hair


August 03rd, 2010, 08:59 AM

There was a recent study that showed positive effects for hair follicles under hypoxic conditions, I will take a closer look and post it later on. If I remember correctly it was stimulating, but I cannot imagine a consistent lack of blood flow being a good thing. 

I believe this is generally the case because inflammation is usually the result of a lack of blood flow (oxygen specifically).

As far as I understand or am aware, most hair transplants seem to have temporary results and the hair eventually miniaturizes after a time. I haven’t really kept too close of tabs on this, so maybe I am wrong.


Now available for consultation (hair and/or health)




August 03rd, 2010, 09:06 AM

But then why can we take a hair follicle from the back of the head, transplant it to the front and it will grow forever?

This, to me, is an argument that I think has done more harm than good!  You can apply that to a lot of treatments, too.  But, I think that the answer here is simply that the hairs are different.  The hairs in the back and sides of your head are different than the hair in the front and crown of your head.  Maybe they have much more receptors that get clogged with DHT -therefore they get weaker easily, and they are prone to the tension.

The hairs on the SIDE of my head are much more prone to getting gray.  I don’t think that’s because something is going on in that area… I think it’s because those hairs are more susceptible to turning gray -and it’s as simple as that.

In the very back sides of my head, my hair is almost as course as horse hair, and it has a wave too it when it grows out -no where else on my head is like that.  The hair is simply DIFFERENT than the other hair.

So, I’ve always felt that the “But when you move a hair from the back and put it in the front…” argument gets us WAY off track.

Once again, there are obviously many elements to hair loss.  If it was just one of the ones we’ve identified, we would have completely solved it by now.  There is something else, though, that we are missing, and I think this muscular aspect might be a very big part of it!


“Reducing blood flow would be how we reduce inflammation.”

I just don’t think that is valid AT ALL, either.  So here is your logical flaw… you are saying that reducing blood flow reduces inflammation -that may be true, but you are then making the flaw that increased blood flow must be CAUSING more inflammation.  That doesn’t have a thing to do with what is CAUSING the inflammation.

There is way more than going on -an most scientists that have looked into this have noticed that there is LESS BLOODFLOW IN THE CAPILARIES with balding people.  Therefore, by your definition, there shouldn’t be ANY inflammation.  That’s just not a valid thing to keep bringing up.

So, I just don’t even think for a second that reducing blood flow to the capilaries in the balding areas would be in any way, shape, or forum something that we would want to do.


Build your own Laser Helmet | Laser Brush | Laser Device at!  The internet’s first, best, and biggest consumer advocate site on laser therapy for hair loss!  It’s time to educate yourself about one of the greatest treatments in FORUM HISTORY…

The Zix Creator

The Zix Creator


August 03rd, 2010, 11:29 AM

Here’s an abstract of the study:

“The author transplanted composite skin grafts from balding, non-balding, and bald areas of the scalp, to the skin of the arm. The galea aponeurotica was trimmed away from the grafts. The patient was a 29-year-old male with progressive male pattern baldness (MPB).

The transplants from the balding area became bald at the same rate as the balding donor site in the receding frontal hairline, whereas the transplants taken from the non-balding in the occiput continued to grow the same amount and quality of terminal hairs. Bald grafts taken in front of the receding hairline remained bald. This shows that the cause of MPB lies in the follicle itself or in its very close surrounding and does not depend on the galea aponeurotica, the increased tension of the scalp or of its muscles; the diminished vascular supply to the scalp or any other regional factor localized to the head area. It also shows that the “balding clock” keeps time even when the follicle is transplanted to another region of the body.”

The Zix Creator

The Zix Creator


August 03rd, 2010, 11:46 AM

“you are saying that reducing blood flow reduces inflammation -that may be true, but you are then making the flaw that increased blood flow must be CAUSING more inflammation.  That doesn’t have a thing to do with what is CAUSING the inflammation.”

No it is injury and destruction of the follicle that is causing inflammatory factors one of which is increased blood flow. Compound this with increased bacterial contamination due to excess sebum. With many diseases it’s not actually the “injury” to the tissue that causes the most damage but the subsequent inflammation.

So….how do we stop all this inflammation? By vasoconstricting the vasculature to a degree.



August 03rd, 2010, 03:02 PM

Damn viruses, a couple specific bacteria and a few other similiar conditions that come with these…

No, I haven’t lost my mind and yes, it explains many of the conditions talked about regarding T, DHT, metals, thyroid, etc..

Immortal Hair

Immortal Hair


August 04th, 2010, 12:43 AM

It is well documented that cancer cells love tissue where there is lack of oxygen, which also turns the tissue PH acidic (the thyroid drives this force greater than anything else).

Tissue that lacks adequate oxygen induces the production of lactic acid, which causes pain.  In addition, a low oxygen environment causes signaling to the brain that more blood vessels are needed in this area.  This signal is known as Hypoxia Inducing Factor HIF). When HIF is present, it results in a growth factor being up-regulated (vascular endothelial growth factor - VEGF), which encourages the growth of new blood vessels to cancer cells.  This is how tumors grow!

So what I’m saying is that if the blood supply is starved of oxygen, it will stimulate more blood vessels to grow.  Here is a recent study demonstrating that fact.

Biomed Res. 2010;31(1):27-34.
Hair growth stimulated by conditioned medium of adipose-derived stem cells is enhanced by hypoxia: evidence of increased growth factor secretion.

Park BS, Kim WS, Choi JS, Kim HK, Won JH, Ohkubo F, Fukuoka H.

Leaders Clinic, Seoul, Korea.

Adipose-derived stem cells (ADSCs) and their secretomes mediate diverse skin-regeneration effects, such as wound-healing and antioxidant protection, that are enhanced by hypoxia. We investigated the hair-growth-promoting effect of conditioned medium (CM) of ADSCs to determine if ADSCs and their secretomes regenerate hair and if hypoxia enhances hair regeneration. If so, we wanted to identify the factors responsible for hypoxia-enhanced hair-regeneration. We found that ADSC-CM administrated subcutaneously induced the anagen phase and increased hair regeneration in C(3)H/NeH mice. In addition, ADSC-CM increased the proliferation of human follicle dermal papilla cells (HFDPCs) and human epithelial keratinocytes (HEKs), which are derived from two major cell types present in hair follicles. We investigated the effect of hypoxia on ADSC function using the same animal model in which hypoxia increased hair regrowth. Forty-one growth factors in ADSC-CM from cells cultured under hypoxic or normoxic conditions were analyzed. The secretion of insulin-like growth factor binding protein (IGFBP)-1, IGFBP-2, macrophage colony-stimulating factor (M-CSF), M-CSF receptor, platelet-derived growth factor receptor-beta, and vascular endothelial growth factor was significantly increased by hypoxia, while the secretion of epithelial growth factor production was decreased. It is reasonable to conclude that ADSCs promote hair growth via a paracrine mechanism that is enhanced by hypoxia.


Now available for consultation (hair and/or health)

The Zix Creator

The Zix Creator


August 05th, 2010, 02:05 AM

Thanks immortal. I see what you’re saying. In short…. even if less blood flow is good, and even if we could figure out a way to reduce blood flow, the body would adapt and build new blood vessels anyway.

You don’t know how much I appreciate that you took the time to explain that to me. I’ve been stuck on that for years.



August 20th, 2010, 04:18 AM

“...lack of blood flow is the main cause of baldness why can we take a hair follicle from the back of the head, transplant it, and it will continue to grow…”

One possible answer that I got from an email conversation, with the guy selling the “skull expansion” theory ebook (this is one of the questions I asked), is that the transplanted hair is inserted deeper into the scalp, where it reaches blood flow.

As opposed to being ever so slightly removed from the blood supply, due to skull shape and growth.

The study you mentioned would seem to disprove this, but we would need to very carefully read the study to see. For example, what is a balding hair? One that is already vellus and dying?

The Zix Creator

The Zix Creator


August 20th, 2010, 05:21 AM

No the balding hair that was used was terminal hair taken from an area predicted to bald. These follicles were transplanted to various parts of the body and yet they still miniaturized within a predictable time frame.




August 23rd, 2010, 03:59 PM


FYI, I’ve heard that the “study” you are referencing actually doesn’t hold water.  I’ll keep my eyes open -and I’ll certainly come back and say that I’m wrong if I find that out to be true- but I’ve heard that what you are talking about either doesn’t hold up to scrutiny or was just completely blown out of proportion.  Either something with the test was drastically wrong, or it never even happened in the first place (or somewhere in between).  So, I’ve been “conditioned” to completely disregard that information.


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August 23rd, 2010, 04:59 PM

Yea I would be interested in that argument against the donor dominance studies. Until I read what you’re talking about I just can’t buy into MPB having anything at all to do with lack of blood flow.

You could be refering to the fact that transplanted hair does take on the characteristics of the hair it is surrounded by. For example if you transfer a scalp hair to an eyebrow the scalp hair follicle starts to grow as if it were an eyebrow hair! But that follicle will still miniaturize at a predictable rate if it is taken from an area of the scalp where it is predicted to go bald.

Furthermore even if blood flow has nothing to do with MPB that doesn’t mean reducing tension may not still be helpful. Perhaps the idea works but we just don’t know how or why?

As you’ve often said John this site is operated by people that actually want to SOLVE HAIR LOSS. That’s why we have to get to the bottom of the whole “more blood flow” is good thing. I personally don’t believe blood flow has anything to do with MPB. I don’t believe that improving blood flow will have anything to do with slowing down the balding condition either. Keep in mind….proving what doesn’t help may change our focus to other things that will help.

Personally I think too much of our time has been devoted to this whole notion that we need to improve blood flow to the follicle. But I’m definitely in the minority here! LOL!




October 03rd, 2010, 12:51 PM

Interesting article and lots of interesting comments.

So if increasing blood flow doesn’t help counter MPB, can we account for how LLLT is supposed to help fight hair loss and cause regrowth? Isn’t one of the factors of laser therapy that it increases the blood flow to the targeted area?

Some days you just can’t get rid of a bomb!



March 05th, 2011, 07:00 AM

I read a book years ago about massage and putting the top of your head in a sink full of very cold water for around 30 sec to a min (depending on how cold it is). Drying with a towel gently and then massage for a few mins. Now at the time I was in my early twenties and had a pretty good head of hair so it was hard to tell if it was working. I got bored with it and got into other things. Now in my 40’s with a 3 and a half year old transplant I am doing this again BUT when I massage I have my head hanging over the edge of the bed lying on my back. I do this every morning and I can tell you the results are very positive. Much thicker hair !

There may be other factors as I started using hairmuck in my Minoxidil last year so it could be that too but I am going to continue with this. A loose scalp can’t be doing anyone any harm. The turning upside down was another theory in a natural baldness book that helps flood the folicles. It’s only takes a minute or so for it to do any good.



October 31st, 2011, 10:22 AM

I know well this theory. In fact I have used this reference in a work that I finished recently about the baldness. I don’t Kwow if míster Hatch achieve to these conclusions by his account, I imagine that if, but the bases of this theory were drawn up it does but of 20 years in Italy by a man who achieve the incredible feat of follicular regeneration. I collaborated with and have advanced much investigation since then. The direction is correct but what Hatch not explain they are well the causes and the actions necessary to restore the balance of the hair cycle.

ps:Please forgive my english

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